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. 2021 Jan 26;11(2):162. doi: 10.3390/biom11020162

Figure 6.

Figure 6

Effects of rosmarinic acid (RA)-loaded nanovesicles (5, 10 and 20 mg/kg), RA (20 mg/kg) or aminosalicylic acid (5-ASA) (75 mg/kg) on nuclear factor erythroid-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression in DSS-induced colitis in mice. (a) Representative Western blot analysis. Densitometry analysis of (b) Nrf2, and (c) HO-1 were performed following normalisation to the control (β-actin housekeeping gene). Results are representative of five experiments performed on different simples. Data are expressed as the mean ± SEM. Mean value was significantly different compared with the sham group (* p < 0.05; Mann–Whitney U test). Mean value was significantly different compared with DSS group (+ p < 0.05, ++ p < 0.01; Kruskal–Wallis test) or RA group (# p < 0.05; Kruskal–Wallis test).