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. 2021 Jan 22;13(2):80. doi: 10.3390/toxins13020080

Table 2.

RIPs active against animal viruses. RIPs with antiviral activity, the families and species from which they have been obtained and the viruses in which this activity has been demonstrated are shown.

Species and RIP Virus References
POACEAE
Zea mays L.
Maize RIP HIV, SHIV [27,28]
EUPHORBIACEAE
Ricinus communis L.
Ricin A chain HIV [29]
Suregada multiflora (A.Juss.) Baill. (=Gelonium multiflorum A.Juss.)
Gelonin HIV, HPV, HSV, PICV, [2,30,31,32]
GAP31 HIV [33,34]
CUCURBITACEAE
Trichosanthes kirilowii Maxim
Trichosanthin (TCS) HBV, HIV, HSV [32,35,36,37,38]
TAP29 HIV [36]
Trichobitacin HIV [36,39]
Momordica charantia L.
Momordin (M. charantia inhibitor) HPV, HSV [30]
Alpha-momorcharin (α-MMC) HBV, HIV, HSV [2,32,40,41]
Beta-momorcharin HIV [2,32]
Momordica antiviral protein (MAP30) DENV-2, HHV8, HBV, HIV, HSV [35,42,43,44,45,46]
Momordica balsamina L.
Balsamin HIV [47]
Luffa cylindrica (L.) M.Roem.
Luffin HIV [32]
Bryonia cretica subsp. dioica (Jacq.) Tutin (=Bryonia dioica Jacq.)
Bryodin HIV [48]
CARYOPHYLLACEAE
Saponaria officinalis L.
Saporin HIV [32,49,50]
Dianthus caryophyllus L.
Dianthin 32 (DAP32) HIV, HPV, HSV [30,34]
Dianthin 30 (DAP30) HIV [34]
Agrostemma githago L.
Agrostin HIV [2,32]
PHYTOLACCACEAE
Phytolacca americana L.
PAP (PAPI) CHIKV, FLUV, HBV, HIV, HPV, [10,35,51,52,53,54,55,56,57]
HSV, HTLV, JEV, LCMV
PAPII HIV [57]
PAPIII HIV [57]
PAP-S HSV, HPV, HBV [30,56]

Virus name abbreviations: CHIKV (chikungunya virus), DENV (dengue virus), FLUV (human influenza virus), HBV (hepatitis B virus), HHV (human gammaherpesvirus), HIV (human immunodeficiency virus), HPV (human poliovirus), HSV (herpes simplex virus), HTLV (human T-cell leukemia virus), JEV (Japanese encephalitis virus), LCMV (lymphocytic choriomeningitis virus), PICV (Pichinde virus), SHIV (simian–human immunodeficiency virus).