Table 2.
Recommended reversal agents for anticoagulant therapy.
| First Line Reversal Agent | Alternative Reversal Agent(s) | |
|---|---|---|
| UFH 1 | Protamine sulfate | |
| LMWH 2 | Protamine sulfate | |
| VKA 3 | 4F-PCC 4 | FFP 5 |
| Dabigatran | Idarucizumab | PCC 6 aPCC 7 |
| Direct oral factor-Xa inhibitors | Andexanet alfa | PCC aPCC |
| Fondaparinux | Factor VIIa | aPCC Andexanet alfa |
1 UFH: Unfractionated heparin; 2 LMWH: low molecular weight heparin; 3 VKA: vitamin K antagonist; 4 4F-PCC: 4-factor prothrombin complex concentrate; 5 FFP: fresh frozen plasma; 6 PCC: prothrombin complex concentrate; 7 aPCC: activated prothrombin complex concentrate.