Table 3.

FDA recommendations of DOACs in liver dysfunction.

	Mild Impairment (Child-Pugh Class A)	Moderate Impairment (Child-Pugh Class B)	Severe Impairment (Child-Pugh Class C)
Apixaban	No dosage adjustment.	Use with caution. No dosage adjustments provided.	Use is not recommended.
Rivaroxaban	No dosage adjustment.	Avoid use.	Avoid use.
Edoxaban	No dosage adjustment.	Use is not recommended.	Use is not recommended.
Dabigatran	No dosage adjustment.	Use with caution. No dosage adjustments provided.	No dosage adjustments provided.