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. 2021 Jan 27;11(2):75. doi: 10.3390/metabo11020075

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sketch for major compartmental modules and related parameters. The subscripts of pv, G, H, HA and sys represent the portal vein, gut, liver, hepatic artery and systemic compartment, respectively. Q is the blood flow rate, K_a is the absorption rate constant, F_G is gut availability after intestinal metabolism; CL_μ,int,H and CL_μ,int,H are the unbound intrinsic clearance in liver and enterocytes. PS_inf is the overall influx intrinsic clearance, PS_eff is the overall efflux intrinsic clearance, and CL_met,int represents the hepatic metabolism by CYPs.