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. 2021 Feb 1;13(2):190. doi: 10.3390/pharmaceutics13020190

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FUSIN delivery of 800CW-aPD-L1 to the brainstem glioma. (A) Fluorescence images of representative ex vivo mouse brainstem slices. The white arrow indicates the tumor location. (B) Spatial distribution of FUSIN-delivered 800CW-aPD-L1. Left panel: aPD-L1 distribution in a coronal section of the brainstem after FUSIN delivery imaged at 2×. Right panel: higher magnification view (60×) of the tumor showing the colocalization of aPD-L1 with the tumor cells. (C) Fluorescence quantification of the 800CW-aPD-L1 delivery efficiency to the brainstem glioma (** p < 0.01).