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Inhibitory effects of magnolin (0.1–200 µM) on UGT1A1-, UGT1A3-, UGT1A4-, UGT1A6-, UGT1A9-, and UGT2B7-mediated glucuronidation of 0.5 μM SN-38, 2 µM chenodeoxycholic acid, 0.5 µM trifluoperazine, 1 µM N-acetylserotonin, 0.2 µM mycophenolic acid, and 1 µM naloxone, a probe substrate for UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, and UGT2B7, respectively, in human liver microsomes. The data are expressed as means ± standard deviations (n = 3).
