Table 2.
Kinetic parameters for the inhibition of eudesmin, fargesin, epimagnolin A, magnolin, and yangambin on UGT1A1 and UGT1A3 enzyme activities in pooled human liver microsomes.
| Ki (μM, Inhibition Mode) | ||
|---|---|---|
| SN-38 Glucuronidation (UGT1A1) | Chenodeoxycholic Acid 24-acyl-Glucuronidation (UGT1A3) | |
| Eudesmin | 25.7 (noncompetitive) | 39.8 (competitive) |
| Fargesin | 25.3 (noncompetitive) | 24.5 (competitive) |
| Epimagnolin A | 3.6 (noncompetitive) | 15.1 (competitive) |
| Magnolin | 26.0 (noncompetitive) | 37.6 (competitive) |
| Yangambin | 17.1 (noncompetitive) | 66.8 (competitive) |