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. 2021 Feb 1;13(2):188. doi: 10.3390/pharmaceutics13020188

Figure 1.

Figure 1

Adjuvant elicited T helper cytokine profiles on human newborn and adult blood. Human cord blood was used as a neonatal blood surrogate in vitro. Cord blood and human adult blood controls were diluted 1:1 with RPMI 1640 and incubated for 6 h in the presence of the neonatal gold standard adjuvant R848 (3.5 µg/mL/10 µM), CDA (5 µg/mL/7.6 µM), and medium control. Spider plots display cytokine values in pg/mL in supernatants of treatments for (A) IL-10, IL-21, and IL-6 (T follicular helper profile, Tfh), TNF-α and IFN-γ (Th1); and (B) IL-17 and IL-22 (T helper 17, Th17), IL-4, IL-5, and IL-13 (T helper 2, Th2) in cord blood (newborn) or adult blood. Results correspond to one out of two independent experiments.