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. 2021 Feb 1;10(2):288. doi: 10.3390/cells10020288

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Kidney-derived T cells differ in CD4/CD8 distribution, contain TrM and have a different memory-profile than PB T cells. (a) Percentage of CD4⁻CD8⁺ (CD8) and CD4⁺CD8⁻ (CD4) T cells within CD3⁺CD45⁺ single-cell live lymphocytes in peripheral blood (PB) and healthy kidney MNC (median with IQR in black). (b) CD4/CD8 ratio within PB and healthy kidney-derived T cells. (c) Distribution of CD69/CD103 based subsets within CD8 and CD4 T cells (median with IQR in black) derived from PB and healthy kidney. (d) Expression patterns of CD27, CD45RA, CCR7 and CD28 within CD8 and CD4 T cells from PB and healthy kidney (median). Mann-Whitney U-test was used for statistical comparison. Only significant p-values are displayed: * p < 0.05, ** p ≤ 0.01, *** p ≤ 0.001.