Skip to main content
. 2021 Feb 1;10(2):288. doi: 10.3390/cells10020288

Figure 7.

Figure 7

CD4 T cells in kidney tissue are more often polyfunctional than their counterparts in blood. (a–e) Percentage of IFNγ-(a), TNFα-(b), GM-CSF-(c), IL-2-(d) and IL-17A-(e) producing CD8 (red) and CD4 (blue) T cells derived from peripheral blood (PB) and healthy kidney after 4 hr stimulation with PMA and ionomycin (median with IQR in black). (f) The average number of cytokines produced by CD8 and CD4 T cells derived from PB and healthy kidney (median with IQR in black). (g–k) Percentage of IFNγ-(a), TNFα-(b), GM-CSF-(i), IL-2-(j) and IL-17A-(k) producing CD103− and CD103+ CD8 (red) and CD4 (blue) T cells derived from kidney after 4 hr stimulation with PMA and ionomycin (median with IQR in black). (l) The average number of cytokines produced by CD103- and CD103+ CD8 and CD4 T cells derived from kidney (median with IQR in black). Statistical comparisons used: (a–d) Mann-Whitney U-test (e,f) Wilcoxon signed rank test. Only significant p-values are displayed: * p < 0.05, ** p ≤ 0.01, *** p ≤ 0.001.