Figure 10.

Structure of X-ray crystallized Bcl-2 (PDB ID: 6qgk) bounded to tetrahydroisoquinoline-phenyl pyrazole derivative along the binding site. Five hydrophobic pockets (P1–5), constituting the binding site, are shown in 3D-surface presentation and differently colored; P1 yellow, P2 magenta, P3 green, P4 red, P5 orange. Zoomed image is stereoview of crystallized ligand (yellow sticks) at binding site. Sub-pockets are labeled with red letters and only significant residues (cyan lines) located within 4 Å radius of bound ligand are displayed and labeled with sequence number.