Table 1.
In-vitro a data of MTT-cell proliferation assay for promising synthesized compounds on both cancerous and non-cancerous cell lines.
| Compound b No. |
MDA-MB-231 IC50 (µM) c |
A549 IC50 (µM) c |
MDCK IC50 (µM) c |
|---|---|---|---|
| 3a | 29.68 ± 4.03 | ND | ND |
| 7b | 43.77 ± 1.09 | ND | 28.92 ± 1.49 |
| 7d | 17.38 ± 3.23 | ND | ND |
| 8a | 12.69 ± 0.84 | ND | 73.86 ± 2.30 |
| 8b | 12.71 ± 2.48 | 23.05 ± 1.45 | 92.75 ± 0.43 |
| 8c | 12.83 ± 3.50 | 11.63 ± 2.57 | 87.29 ± 3.00 |
| 8d | 31.46 ± 4.66 | ND | ND |
| 8f | 21.64 ± 0.28 | ND | ND |
a In-vitro data are reported as mean of three independent experiments ± SEM; b Tested compounds were those depicted % cell viability < 85%, on both cancerous cell lines, at their respective 100 µM concentrations; c IC50 values represent effective concentration of given small molecule being capable of inducing 50% inhibitory response of its own intrinsic maximum response following 48 h of drug exposure; ND = Not-detected.