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. 2021 Feb 1;14(2):113. doi: 10.3390/ph14020113

Table 2.

The formulation factors and responses of 23 factorial design for drug-solid lipid nanoparticles (SLNs).

Factors and Responses Level Used
Factor Name Low (−1) High (+1)
A: X1 Type of lipid Compritol 888 ATO (COMP) Glyceryl Monostearate (GMS)
B: X2 Type of surfactant Cremophor RH40 Poloxamer 188
C: X3 Surfactant conc. (% w/v) 1% 1.5%
Response Name Goal
Y1 EE (%) Maximize
Y2 PS (nm) Minimize
Y3 ZP (mV) Maximize