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. 2021 Feb 1;10(2):292. doi: 10.3390/cells10020292

Figure 3.

Figure 3

Signal transduction of GnRH-I and GnRH-II and their agonistic as well as antagonistic analogs through the GnRH-I-R if no functional GnRH-II-R is expressed. For details, cf. Figure 1 and Figure 2. AP-1, activvator protein-1. Bax, B-cell lymphoma 2 (Bcl-2)-associated X protein. EGF, epidermal growth factor. EGF-R, EGF receptor. ERK1/2, p44/42 mitogen-activated protein (MAP) kinase. GDP, guanosindiphosphat. GnRH, gonadotropin releasing hormone. JNK, c-Jun N-terminale kinase. JunD, transcription factor JunD. P38, mitogen-activated protein kinase P38. PI3K, phosphoinositide 3-kinase. PTP, protein tyrosine phosphatase.