Table 1.
Relative abundance of fecal microbiota in mice treated with different doses of OTA.
| Phylum | Family | Control | OTA 0.21 | OTA 0.5 | OTA 1.5 |
|---|---|---|---|---|---|
| Unclassified | Unclassified | 0.47 ± 0.12 | 0.50 ± 0.05 | 0.46 ± 0.11 | 0.42 ± 0.05 |
| Bacteroidetes | Unclassified Bacteroidales | 0.32 ± 0.03 | 0.46 ± 0.09 * | 0.44 ± 0.07 * | 0.41 ± 0.07 * |
| Bacteroidaceae | 2.16 ± 0.30 | 3.45 ± 0.46 | 2.68 ± 0.66 | 2.37 ± 0.29 | |
| Porphyromonadaceae | 0.11 ± 0.01 | 0.20 ± 0.06 * | 0.15 ± 0.02 * | 0.19 ± 0.02 * | |
| Prevotellaceae | 1.14 ± 0.06 | 1.19 ± 0.04 | 1.22 ± 0.07 | 1.17 ± 0.04 | |
| Rikenellaceae | 4.75 ± 0.10 | 5.09 ± 0.23 | 4.72 ± 0.33 | 4.77 ± 0.36 | |
| S24-7 | 24.87 ± 1.42 | 28.62 ± 2.29 | 28.71 ± 2.41 | 25.60 ± 1.70 | |
| Odoribacteraceae | 0.63 ± 0.32 | 0.78 ± 0.03 | 0.82 ± 0.05 | 0.77 ± 0.16 | |
| Cyanobacteria | Unclassified Cyanobacteria | 0.90 ± 0.08 | 0.94 ± 0.04 | 0.84 ± 0.06 | 0.68 ± 0.07 * |
| Deferribacteres | Deferribacteraceae | 0.47 ± 0.09 | 0.45 ± 0.10 | 0.48 ± 0.24 | 0.47 ± 0.04 |
| Firmicutes | Lactobacillaceae | 0.92 ± 0.30 | 0.99 ± 0.76 | 1.52 ± 0.13 | 1.44 ± 0.08 |
| Streptococcaceae | 0.02 ± 0.03 | 0.24 ± 0.12 * | 0.19 ± 0.18 * | 0.03 ± 0.03 | |
| Unclassified Clostridiales | 34.55 ± 1.47 | 28.60 ± 2.44 | 30.35 ± 2.30 | 32.71 ± 2.79 | |
| Clostridiaceae | 0.28 ± 0.12 | 0.40 ± 0.09 | 0.36 ± 0.10 | 0.28 ± 0.04 | |
| Dehalobacteriaceae | 0.57 ± 0.03 | 0.62 ± 0.05 | 0.57 ± 0.05 | 0.54 ± 0.06 | |
| Lachnospiraceae | 8.05 ± 0.96 | 7.58 ± 0.45 | 8.63 ± 1.69 | 9.13 ± 1.29 | |
| Peptococcaceae | 0.17 ± 0.09 | 0.20 ± 0.04 | 0.20 ± 0.14 | 0.17 ± 0.05 | |
| Ruminococcaceae | 15.61 ± 0.66 | 15.58 ± 0.48 | 13.40 ± 1.43 * | 14.96 ± 0.82 | |
| Mogibacteriaceae | 0.14 ± 0.09 | 0.19 ± 0.03 | 0.15 ± 0.04 | 0.17 ± 0.03 | |
| Erysipelotrichaceae | 0.62 ± 0.22 | 0.32 ± 0.07 | 0.59 ± 0.17 | 0.56 ± 0.10 | |
| Proteobacteria | Unclassified Alphaproteobacteria | 0.81 ± 0.20 | 0.84 ± 0.21 | 0.73 ± 0.15 | 0.68 ± 0.27 |
| Alcaligenaceae | 0.44 ± 0.04 | 0.41 ± 0.02 | 0.44 ± 0.04 | 0.38 ± 0.03 | |
| Desulfovibrionaceae | 0.39 ± 0.06 | 0.40 ± 0.09 | 0.42 ± 0.02 | 0.43 ± 0.06 | |
| Enterobacteriaceae | 0.08 ± 0.02 | 0.36 ± 0.15 * | 0.36 ± 0.31 * | 0.09 ± 0.07 | |
| TM7 | F16 | 0.23 ± 0.07 | 0.21 ± 0.01 | 0.27 ± 0.01 | 0.23 ± 0.02 |
| Tenericutes | Anaeroplasmataceae | 0.73 ± 0.07 | 0.79 ± 0.28 | 0.76 ± 0.18 | 0.87 ± 0.06 |
| Unclassified Mollicutes | 0.54 ± 0.30 | 0.59 ± 0.15 | 0.54 ± 0.05 | 0.48 ± 0.07 |
Data are shown as mean ± standard deviation (n = 3–4). Statistical significance was determined by non-parametric Kruskal–Wallis test followed by Mann–Whitney U test; * p <0.05 significantly different from control mice.