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The PI3-K/Akt/mTOR signaling cascade. Stimulation of receptor tyrosine kinases (RTK) and G-protein-coupled receptors (GPCR) leads to activation of PI3-K, which then synthesizes PIP3 in the membrane. Subsequently, Akt is recruited to the membrane and phosphorylated by PDK-1 and mTORC2, modified from Hu et al., 2020 [4].
