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. 2021 Feb 2;10(2):218. doi: 10.3390/antiox10020218

Figure 3.

Figure 3

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. (A) NOX2 isoform requires p67phox, p47phox, Rac and p40phox to be activated, then these cytosolic subunits need to be translocated from the cytosol to the membrane and bound to gp91phox and p22phox (membrane subunits) in order to produce the active complex. (B) NOX4 isoform requires protein disulfide isomerase (PDI), poldip2 and TKS4/5 for its activation, however, is not known if each one is able to activate NOX4 independently from the others. Furthermore, NOX4 can interact with Toll-like receptor 4 (TLR4).