Table 1.

Regions of the brain in rats, mice and humans in which NOX2 and NOX4 are overexpressed. * RNA expression taken from proteinatlas.org.

NADPH Oxidase Isoform	Species
	Rat	Mouse	Human
NOX2	Medulla, superior colliculus, thalamus, hippocampus, hypothalamus, substantia nigra, striatum and cortex [86,87]	Thalamus, hippocampus, cerebellum, forebrain, midbrain, hindbrain, hypothalamus, substantia nigra, amygdala, striatum, cortex [86,88,89] (Cerebral cortex, olfactory region, basal ganglia, hypothalamus, thalamus, pons and medulla, hippocampus, amygdala, midbrain, retina, corpus callosum and cerebellum) *	(Cerebral cortex, olfactory region, basal ganglia, thalamus, hypothalamus, pons and medulla, hippocampus, amygdala, midbrain and cerebellum) *
NOX4		Hippocampus, cortex cerebellum, forebrain, midbrain, hindbrain, hypothalamus [86] (Cerebral cortex, olfactory region, basal ganglia, thalamus, hypothalamus, pons and medulla and pituitary gland) *	Brain cells [61,90] (Cerebral cortex, olfactory region, basal ganglia, hypothalamus, pons and medulla, hippocampus, amygdala, midbrain and cerebellum) *