Table 2.

Transgenic model [117] taken from alzforum.org. * Cerebral amyloid angiopathy, ** hereditary cerebral hemorrhage with amyloidosis of the Dutch type.

	Species Model		Gene Expression			Disease	Phenotype Characterization
	Mouse	Rat	APP	PSEN 1	MAPT		Plaques Aβ42	Tangles	Neuronal Loss	Gliosis	Synaptic Loss	Changes In LTP/LTD	Cognitive Impairment
PDAPP [118]	✓		✓	X	X	AD	✓	X	X	✓	✓	✓	✓
Tg2576 [119,120,121]	✓		✓	X	X	AD	✓	X	X	✓	✓	✓	✓
APP23 [122,123,124]	✓		✓	X	X	AD/CAA *	✓	X	✓	✓	X	X	✓
J20 (PDGF-APPSw, Ind)	✓		✓	X	X	AD	✓	X	✓	✓	✓	✓	✓
APP/PS1	✓		✓	✓	X	AD	✓	X	✓	✓	✓	✓	✓
APPswe/PS1dE9	✓		✓	✓	X	AD	✓	X	✓	✓	✓	✓	✓
Tg-SwDI	✓		✓	X	X	AD/CAA/HCH **	✓	X	Unknown	✓	Unknown	X	✓
APPE693-Δ-Tg	✓		✓	X	X	AD	X	X	✓	✓	✓	✓	✓
APP NL-G-F knock-in	✓		✓	X	X	AD	✓	X	X	✓	✓	Unknown	✓
3xTg	✓		✓	✓	✓	AD	✓	✓	Unknown	✓	X	✓	✓
5xFAD	✓		✓	✓	X	AD	✓	X	✓	✓	✓	✓	✓
PS/APP	✓		✓	✓	X	AD	✓	X	✓	✓	Unknown	Unknown	✓
TgF344-AD		✓	✓	✓	X	AD	✓	✓	✓	✓	X	X	✓
McGill-R-ThyI-APP		✓	✓	X	X	AD	✓	X	✓	✓	✓	✓	✓