Figure 3.

In vitro activities of azoles alone and in combinations including FLC-ITC 25–4 µg/mL (a), FLC-VRC 25–1 µg/mL; (b), FLC-POS 25–4 µg/mL; (c), ITC-VRC 4–1 µg/mL; (d), ITC-POS 4–4 µg/mL; (e), and VRC-POS 1–4 µg/mL; (f) against C. glabrata IFM60089 as determined by the time-killing assay. The detection limit was 20 CFU/mL. Dashed lines represent a >99.9% growth reduction compared with the initial inoculum size for determination of fungicidal activity. All azole combinations showed indifferent interactions. Each data point represents the means ± standard deviation of results from two independent experiments.