Table 4.
Complete characterization of the combinations with synergism.
| No. | IFM | FKS Mutations | Echinocandin Resistance d | Combinations a,b | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAS-FLC | CAS-ITC | CAS-VRC | CAS-POS | CAS-AMB | AMB-FLC | AMB-ITC | AMB-VRC | AMB-POS | ||||
| 1 | 60089 | FKS1 S629P | R | + (0.38) |
+ (0.38) |
+ (0.49) |
+ (0.28) |
+ (0.38) |
- | - | - | - |
| 2 | 61000 | S | - | - | - | - | - | - | - | - | - | |
| 3 | 61017 | S | - | - | - | - | - | - | - | - | - | |
| 4 | 61169 | S | - | - | - | - | - | - | - | - | - | |
| 5 | 61186 | S | - | - | - | - | - | - | - | - | - | |
| 6 | 61193 | S | - | - | - | - | - | - | - | - | - | |
| 7 | 61743 | S | - | - | - | - | - | - | - | - | - | |
| 8 | 61756 | S | - | - | - | - | - | - | - | - | + (0.38) |
|
| 9 | 62339 | S | - | - | - | - | - | - | - | - | + (0.50) |
|
| 10 | 64652 | S | - | - | - | - | - | - | - | - | + (0.50) |
|
| 11 | 64679 | FKS2 S663P c | R | + (0.50) |
+ (0.50) |
- | - | - | - | - | - | - |
| 12 | 64684 | FKS2 S663P c | R | - | - | - | - | - | - | - | - | - |
| 13 | 64686 | FKS2 S663P c | R | + (0.38) |
+ (0.50) |
+ (0.38) |
+ (0.5) |
+ (0.38) |
+ (0.25) |
+ (0.19) |
+ (0.09) |
+ (0.31) |
| 14 | 64689 | FKS2 S663P c | R | + (0.50) |
+ (0.38) |
+ (0.38) |
+ (0.38) |
+ (0.25) |
+ (0.31) |
+ (0.38) |
+ (0.50) |
+ (0.50) |
| 15 | 64903 | S | - | - | - | - | - | - | - | - | - | |
| 16 | 64905 | S | - | - | - | - | - | - | - | - | - | |
| 17 | 58273 | FKS2 F659del | R | - | + (0.50) |
- | - | + (0.38) |
- | - | - | - |
a CAS, caspofungin; FLC, fluconazole; ITC, itraconazole; VRC, voriconazole; POS, posaconazole; AMB, amphotericin B. b + Indicate synergism (FICI), - indicate indifference. c Four isolates with FKS2 S663P from the same patient with different MIC values. d R indicate echinocandin resistant, S indicate echinocandin susceptible.