Table 1.
Demographic and laboratory characteristics of the included 4211 patients.
| Non-Cirrhotic CLD (n = 985) | Cirrhosis (n = 2141) | HCC (n = 1085) | p | |
|---|---|---|---|---|
| Sex (M/F) | 620/365 | 1338/803 | 926/159 | <0.0001 |
| Age (year) | 44.00 (35.00–51.00) | 50.00 (43.00–58.00) | 52.00 (45.00–59.00) | <0.0001 |
| BMI (kg/m2) | 24.26 (21.86–26.62) | 23.83 (21.50–26.37) | 23.88 (21.79–25.95) | 0.033 |
| ALT (U/L) | 26.00 (17.00–48.00) | 30.00 (20.00–55.00) | 36.00 (24.00–60.00) | <0.0001 |
| AST (U/L) | 25.00 (20.00–38.00) | 41.00 (27.00–71.00) | 40.00 (28.00–69.75) | <0.0001 |
| GGT (U/L) | 25.00 (16.00–54.00) | 44.00 (24.00–97.00) | 58.00 (33.00–127.00) | <0.0001 |
| ALP (U/L) | 77.00 (62.00–99.00) | 99.00 (75.00–138.50) | 98.00 (76.00–136.00) | <0.0001 |
| ALB (g/L) | 40.00 (38.00–43.00) | 35.00 (30.00–39.00) | 38.00 (35.00–41.00) | <0.0001 |
| PA (mg/L) | 198.00 (158.00–231.00) | 113.00 (72.75–162.00) | 153.00 (110.00–198.00) | <0.0001 |
| TBiL (μmol/L) | 11.70 (8.90–16.10) | 18.30 (12.05–31.80) | 14.60 (10.70–20.08) | <0.0001 |
| DBiL (μmol/L) | 4.20 (3.00–5.95) | 7.50 (4.50–16.20) | 6.20 (4.30–10.20) | <0.0001 |
| CHE (U/L) | 7216.00 (5945.50–8329.50) | 4525.00 (2925.50–6248.00) | 4375.00 (3027.50–6093.50) | <0.0001 |
| GP73 (ng/mL) | 46.42 (30.60–66.90) | 127.90 (82.56–192.40) | 100.50 (60.62–161.50) | <0.0001 |
| PLT (× 109/L) | 176.00 (139.00–215.00) | 92.00 (57.00–142.00) | 134.00 (87.25–181.00) | <0.0001 |
| TBA (μmol/L) | 5.00 (3.00–10.00) | 21.00 (7.00–53.00) | 9.00 (5.00–18.00) | <0.0001 |
| PT (s) | 11.00 (10.40–11.70) | 12.50 (11.40–14.30) | 11.90 (11.10–12.90) | <0.0001 |
Quantitative variables are expressed as the median (interquartile range). Abbreviation: CLD, chronic liver disease; HCC, hepatocellular carcinoma; F, female; M, male; BMI, body mass index; ALT, alanine transaminase; AST, aspartate transaminase; GGT, gamma glutamyl transpeptidase; ALP, alkaline phosphatase; ALB, albumin; PA, prealbumin; TBil, total bilirubin; DBil, direct bilirubin; CHE, cholinesterase; GP73, Golgi protein 73; PLT, platelet; TBA, total bile acid; PT, prothrombin time. A p-value < 0.05 was considered significant. Statistical analysis was performed using SPSS 24.0 software.