Figure A4.

Combined histopathological scores for ceca following oral vaccination of hamsters with recombinant CD0873 and challenge with a hypervirulent strain of Clostridioides difficile. Sections were taken from naïve hamsters, hamsters vaccinated orally with recombinant CD0873 and hamsters vaccinated i.m. with toxoids. Scoring included oedema (0–3), neutrophil infiltration (0–3) and tissue damage (0–3) for each animal group with 0, normal and 3, severe. Combined scores of the 3 groups were compared by a non-parametric Mann–Whitney U test and non significance (ns) detected (p > 0.05).