Figure 2.

sEVs are carriers of a complex biologically active cargo [27] (modified). The figure presents selected molecules carried within sEVs that are involved in inflammatory airway diseases. The biogenesis of sEVs begins when cargos for secretion are located in early endosomes, (1) which accumulate intraluminal vesicles (2) and later convert to multivesicular bodies (MVBs) (3). MVBs might fuse with lysosomes and degrade (4) or fuse with the plasma membrane, (5) releasing sEVs into the intercellular space.