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. 2021 Feb 2;12(2):216. doi: 10.3390/genes12020216

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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GO terms (A–C) and pathway (D,E) gene set enrichment analysis for C5 genes. The analyses were carried out using four tools: David, Enrichr, GeneMANIA, and WebGestalt. Each tool identified pathways that belonged to different GO categories or Kyoto Encyclopaedia of Genes and Genomes (KEGG) or Reactome pathways. We clustered the results by pathway class. Note, GeneMANIA outcomes were annotated and classified to only three GO classes. We then plotted the ten most significant pathways within each GO class (for full results, see Table S5.2.6).

GO terms (A–C) and pathway (D,E) gene set enrichment analysis for C5 genes. The analyses were carried out using four tools: David, Enrichr, GeneMANIA, and WebGestalt. Each tool identified pathways that belonged to different GO categories or Kyoto Encyclopaedia of Genes and Genomes (KEGG) or Reactome pathways. We clustered the results by pathway class. Note, GeneMANIA outcomes were annotated and classified to only three GO classes. We then plotted the ten most significant pathways within each GO class (for full results, see Table S5.2.6).