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. 2021 Feb 3;22(4):1504. doi: 10.3390/ijms22041504

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of ATR inhibition on radiotherapy (RT) response of HPV-negative and HPV-positive head HNSCC cells. HPV-negative (SQD9, CAL27, and SCC61) and HPV-positive (SCC154, SCC104, and SCC47) cells pre-treated for 2 h with DMSO or AZD6738 were irradiated with the indicated RT doses. Clonogenic cell survival is shown as the mean clonogenic survival fraction ± s.e.m., n = 3. P-values were calculated with two-way ANOVA with Bonferroni correction for multiple testing. The dose enhancement factor at 2Gy (DEF2Gy) is defined as the ratio of average survival at 2Gy of the control samples divided by the average survival at 2Gy of 0.25 or 0.5 µM treated samples.