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. 2021 Feb 2;11(2):184. doi: 10.3390/brainsci11020184

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Drug inhibition of AChE within SH-SY5Y cells: Human neuroblastoma cells were incubated with donepezil (Don), tacrine (Tac), berberine (Ber), and galantamine (Gal) and the level of cholinesterase inhibition quantified (A). Combination index (CI) plot of dual-drug inhibition of AChE (B). BerTac = berberine and tacrine; BerGal = berberine and galantamine; TacDon = tacrine and donepezil; DonGal = donepezil and galantamine; DonBer = donepezil and berberine; TacGal = tacrine and galantamine.