Table 1.
Quantitation of interactions between ChEI drugs, dual-drug combinations, and human and Torpedo californica AChE.
| Drug or Drug Combination | CI Value | Acetycholinesterase Inhibition (IC50) (nM) | |||
|---|---|---|---|---|---|
| Donepezil | Tacrine | Berberine | Galantamine | ||
| Don | 57 (h) | ||||
| 91 (tc) | |||||
| Tac | 726 (h) | ||||
| 271 (tc) | |||||
| Ber | 3131 (h) | ||||
| 3234 (tc) | |||||
| Gal | 4183 (h) | ||||
| 4173 (tc) | |||||
| BerTac | 0.880 (h) | 302 (h) | 1451 (h) | ||
| 0.826 (tc) | 99 (tc) | 1486 (tc) | |||
| BerGal | 0.615 (h) | 1101 (h) | 1101 (h) | ||
| 0.744 (tc) | 1355 (tc) | 1355 (tc) | |||
| TacDon | 0.887 (h) | 27 (h) | 299 (h) | ||
| 0.697 (tc) | 29 (tc) | 103 (tc) | |||
| DonGal | 0.876 (h) | 29 (h) | 1538 (h) | ||
| 1.216 (tc) | 51 (tc) | 2729 (tc) | |||
| DonBer | 1.099 (h) | 32 (h) | 1690 (h) | ||
| 1.233 (tc) | 45 (tc) | 2393 (tc) | |||
| TacGal | 1.235 (h) | 489 (h) | 2349 (h) | ||
| 1.139 (tc) | 156 (tc) | 2344 (tc) | |||
Don = Donepezil; Tac = tacrine; Ber = berberine; Gal = galantamine. BerTac = berberine and tacrine; BerGal = berberine and galantamine; TacDon = tacrine and donepezil; DonGal = donepezil and galantamine; DonBer = donepezil and berberine; TacGal = tacrine and galantamine. (h) = human; tc = Torpedo californica. Combination Index values (CI): Synergism: CI < 1; Additive: CL = 1; Antagonism: CI > 1.