Table 2.
Quantitation of interactions between ChEI drugs, dual-drug combinations, and neuronal AChE.
| Drug or Drug Combination | CI Value | Acetylcholinesterase Inhibition (IC50) (nM) | |||
|---|---|---|---|---|---|
| Donepezil | Tacrine | Berberine | Galantamine | ||
| Don | 81 | ||||
| Tac | 1019 | ||||
| Ber | 4844 | ||||
| Gal | 7009 | ||||
| BerTac | 0.686 | 348 | 1670 | ||
| BerGal | 0.575 | 1648 | 1648 | ||
| TacDon | 0.963 | 41 | 461 | ||
| DonGal | 0.804 | 40 | 2152 | ||
| DonBer | 0.834 | 36 | 1907 | ||
| TacGal | 1.100 | 660 | 3169 | ||
Don = donepezil; Tac = tacrine; Ber = berberine; Gal = galantamine. BerTac = berberine and tacrine; BerGal = berberine and galantamine; TacDon = tacrine and donepezil; DonGal = donepezil and galantamine; DonBer = donepezil and berberine; TacGal = tacrine and galantamine. (h) = human; tc = Torpedo californica. Combination index values (CI); Synergism: CI < 1; Additive: CI = 1; Antagonism: CI > 1.