Figure 2.

Minimum endoxifen concentrations at steady-state (C_{SS,min ENDX}) for different CYP2D6 genotype-predicted phenotypes in the five dosing strategies in strictly adherent patients (green), patients missing one dose per week (orange) and patients missing two consecutive doses per week (red) for six months, see Figure 1. Red dashed horizontal line: proposed endoxifen therapeutic threshold concentration (5.97 ng/mL) [7]; boxes: interquartile line (IQR) including median; whiskers: range from hinge to lowest/highest value within 1.5 IQR; points: data outside whiskers. Abbreviations: gNM, gIM, and gPM: genotype-predicted normal, intermediate, and poor metabolisers, respectively.