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Risks for non-attainment of target minimum endoxifen concentrations at steady-state (CSS,min ENDX) in the different dosing regimens in fully adherent patients, patients missing one dose per week and patients missing two consecutive doses per week for six months. Green: gNM, yellow: gIM, red: gPM, blue: overall. Abbreviations: MIPD: model-informed precision dosing; gNM, gIM, and gPM: genotype-predicted normal, intermediate, and poor metabolisers, respectively.
