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(a) Flow cytometry identification of total EVs, leukocyte-derived (CD45+ events) and endothelial-derived (CD41a−/CD31+/CD45− events) EVs in peripheral blood samples. The hierarchy of the gating strategy is represented. (b) Box plot diagram showing median blood concentration before treatment (horizontal black lines) of total EVs and EV subtypes in the overall population and in the two study groups. Extreme values are not shown.
