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. 2021 Feb 3;13(4):585. doi: 10.3390/cancers13040585

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Relationship between response to ICIs and blood circulating endothelial-derived EV concentration at treatment baseline. In panel (a), boxplot diagram showing difference in median endothelial-derived EV concentration (horizontal black lines) between responders and non-responders. Two-tailed Mann–Whitney test was performed, and p value is shown. In panel (b), receiver operating characteristic (ROC) curve illustrating predictive abilities on ICI response of blood circulating endothelial-derived EVs. In panel (c), histograms showing difference in disease control rate (DCR) according to baseline endothelial-derived EV concentration (cut-off point: 94 EVs/ μL). Blue and red bars indicate proportion of responders and non-responders, respectively. Fisher’s exact test was used to compare the two groups.