Table 5.
Association between 8-OhdG and 4-HNE and GI, PBI, or CPITN.
| Index | RA Group | non-RA Group | ||||||
|---|---|---|---|---|---|---|---|---|
| T0 | T1 | T2 |
p for F ANOVA Test |
T0 | T1 | T2 |
p for F ANOVA Test |
|
| 8-OHdG, mean±SD | ||||||||
| GI 1 2 3 4 |
- 39.54 ± 3.06 41.63 ± 8.66 40.01 ± 8.72 |
7.14 ± 2.82 8.87 ± 4.79 10.29 ± 4.95 10.30 ± 8.34 |
4.08 ± 1.73 4.93 ± 2.19 7.35 ± 2.35 - |
0.001 0.001 0.001 0.001 |
- 30.74 ± 3.96 31.37 ± 4.89 33.11 ± 6.12 |
8.46 ± 4.52 9.71 ± 4.72 8.23 ± 3.68 - |
3.62 ± 0.71 5.36 ± 2.55 6.76 ± 2.65 - |
0.001 0.001 0.001 - |
| p F ANOVA test | 0.870 | 0.268 | 0.001 | - | 0.366 | 0.385 | 0.001 | - |
| 4-HNE, mean ± SD | ||||||||
| GI 1 2 3 4 |
- 32.96 ± 1.59 32.86 ± 4.08 33.91 ± 3.76 |
9.94 ± 4.79 9.06 ± 4.96 9.44 ± 5.11 11.15 ± 4.74 |
1.84 ± 0.74 2.12 ± 0.94 3.03 ± 0.86 - |
0.001 0.001 0.001 0.001 |
- 31.76 ± 3.16 32.19 ± 2.33 32.95 ± 2.94 |
24.86 ± 3.15 26.25 ± 2.89 25.74 ± 2.51 - |
14.07 ± 3.04 15.45 ± 3.17 16.93 ± 2.85 - |
0.001 0.007 0.007 - |
| p F ANOVA test | 0.491 | 0.904 | 0.001 | - | 0.423 | 0.272 | 0.050 | |
| 8-OHdG, mean ± SD | ||||||||
| PBI 0 1 2 3 4 |
- 34.90 ± 0.0 40.90 ± 7.16 41.63 ± 9.75 41.09 ± 9.06 |
6.40 ± 0.82 8.11 ± 3.61 8.82 ± 4.95 13.26 ± 4.26 - |
3.58 ± 0.36 3.90 ± 1.58 5.55 ± 2.43 7.68 ± 1.99 - |
0.001 0.001 0.001 0.001 - |
- - 28.55 ± 4.44 31.23 ± 4.67 33.81 ± 5.94 |
- 5.99 ± 0.77 10.08 ± 4.75 7.55 ± 2.77 - |
3.30 ± 0.21 5.25 ± 2.30 4.69 ± 2.13 7.83 ± 3.27 - |
- 0.995 0.001 0.001 - |
| p F ANOVA test | 0.892 | 0.017 | 0.001 | - | 0.035 | 0.007 | 0.003 | |
| 4-HNE, mean ± SD | ||||||||
| PBI 0 1 2 3 4 |
- 32.90 ± 0.0 32.97 ± 4.21 33.27 ± 3.61 34.11 ± 3.89 |
7.37 ± 3.18 9.37 ± 5.14 8.99 ± 4.90 11.73 ± 4.71 - |
1.60 ± 0.52 1.82 ± 0.77 2.28 ± 0.96 3.38 ± 0.42 - |
0.001 0.001 0.001 0.001 - |
- - 31.35 ± 1.92 32.23 ± 2.21 32.95 ± 3.22 |
- 24.63 ± 2.06 26.32 ± 2.42 25.33 ± 2.70 - |
14.22 ± 1.99 15.78 ± 2.36 15.03 ± 2.67 15.47 ± 7.42 - |
- 0.049 0.001 0.001 - |
| p F ANOVA test | 0.815 | 0.534 | 0.038 | - | 0.309 | 0.075 | 0.692 | |
| 8-OHdG, mean±SD | ||||||||
| CPITN 0 1 2 3 4 |
- - - 39.16 ± 8.75 42.77 ± 8.46 |
- - 7.13 ± 4.19 9.76 ± 4.88 7.85 ± 3.62 |
3.10 ± 0.0 3.40 ± 0.36 4.44 ± 2.05 5.49 ± 2.43 - |
- - 0.001 0.001 0.001 |
- - - 30.53 ± 5.27 33.18 ± 5.01 |
- 5.30 ± 0.14 8.85 ± 4.47 9.85 ± 4.46 7.40 ± 0.0 |
- 14.91 ± 1.69 15.15 ± 3.09 15.99 ± 4.39 - |
- 0.001 0.041 0.001 0.001 |
| p F ANOVA test | 0.069 | 0.142 | 0.050 | - | 0.023 | 0.454 | 0.001 | |
| 4-HNE, mean±SD | ||||||||
| CPITN 0 1 2 3 4 |
- - - 32.21 ± 5.10 34.26 ± 2.06 |
- - 7.99 ± 4.71 9.73 ± 5.18 9.08 ± 3.38 |
2.20 ± 0.0 1.43 ± 0.56 1.86 ± 0.82 2.40 ± 0.97 - |
- - 0.001 0.001 0.001 |
- - - 31.80 ± 2.41 32.98 ± 2.64 |
- 22.90 ± 1.12 25.78 ± 2.36 26.23 ± 2.52 29.60 ± 0.0 |
- 3.53 ± 0.31 4.93 ± 2.24 6.92 ± 2.96 - |
- 0.001 0.001 0.001 0.112 |
| p F ANOVA test | 0.017 | 0.534 | 0.001 | - | 0.043 | 0.116 | 0.629 | |
T0—before periodontal treatment; T1—after 3 therapy sessions; T2—6 months after the end of periodontal therapy. C—control: scaling and root planning (SRP) sites; L—SRP + laser sites; PDT—SRP + photodisinfection sites; RA—rheumatoid arthritis + periodontal disease patients; non-RA—systemically healthy periodontal disease patients; PD—pocket probing depth; GI—gingival index; PBI—papillary bleeding index; CPITN—community periodontal index of treatment needs; 8-OHdG—8-hydroxy-2’-deoxyguanosine; 4-HNE—hydroxynonenal. p < 0.05 was considered statistically significant.