Table 4.

Catalog of common and unique TP53 mutations for colon cancer.

Protein Mutation	Exon/Intron	Residue Function	Domain Function	Structural Motif
C141Y	5 exon	Buried	DNA binding	NDBL/beta-sheets
R175H	5 exon	Buried	DNA binding	L2/L3
R213L	6 exon	Buried	DNA binding	NDBL/beta-sheets
I232S	7 exon	Buried	DNA binding	NDBL/beta-sheets
M237K	7 exon	Buried	DNA binding	L2/L3
C238S	7 exon	Zn binding	DNA binding	L2/L3
C238S	7 exon	Zn binding	DNA binding	L2/L3
G244S	7 exon	Exposed	DNA binding	L2/L3
G245S	7 exon	Buried	DNA binding	L2/L3
R248Q	7 exon	DNA binding	DNA binding	L2/L3
R248Q	7 exon	DNA binding	DNA binding	L2/L3
R273C	8 exon	DNA binding	DNA binding	L1/S/H2
R273H	8 exon	DNA binding	DNA binding	L1/S/H2
E286K	8 exon	Partially exposed	DNA binding	L1/S/H2
E286K	8 exon	Partially exposed	DNA binding	L1/S/H2
E286G	8 exon	Partially exposed	DNA binding	L1/S/H2
E286G	8 exon	Partially exposed	DNA binding	L1/S/H2

IARC TP53 Database search results for TP53 mutations in colon cancer patients. Most mutations are in exon 5, 7, and 8 located in the DNA binding domain.