Effect of oral treatment of NHFMEWF and EAFMEWF in mice on (A) forced swimming test, and (B) tail suspension test, against vehicle-treated (control) and fluoxetine-treated (reference antidepressant) group. NHFMEWF (100 and 200 mg/kg), EAFMEWF (100 and 200 mg/kg), and fluoxetine (25 mg/kg) were administered 30 min prior to the tests. Each column represents mean ± SEM (n = 5 animals). b p < 0.01, a p < 0.001 vs. control group (one way ANOVA followed by Dunnett’s Test). CTR, control; FLX, fluoxetine HCl; NHFMEWF, n-hexane fraction of methanol extract of W. fruticosa leaves; EAFMEWF, ethyl acetate fraction of methanol extract of W. fruticosa leaves.