Fig. 7.

MiR-223 reduced donor T cells homing to recipient tissues and organs. The red CM-dil-labeled splenic T cells and bone marrow cells were transplanted into aGvHD mice. On day 3, the CM-dil-labeled splenic T cells migrated to recipient mice spleen, liver, and intestine in vivo. Compared with NC and aGvHD group, significant decline was noticed in the CM-dil-labeled splenic T cells in miR-223 group (a). Compared with NC and aGvHD group, the average number of red CM-dil-labeled cells in spleen, liver, or intestine showed a significant decline in miR-223 group (b). Five fields were randomly in 5 mice. Data were presented as mean ± SEM. Measured in three independent experiments, n = 5 per group. *P < 0.05, **P < 0.01, ***P < 0.001