ACE	Angiotensin converting enzyme
APACC	Association pour la Prevention par l’Aspirine du Cancer Colorectal
APC	Adenomatous polyposis coli
ASA	Aspirin
BCL-2	B-cell lymphoma 2
CAPP2	The Colorectal/Adenoma/Carcinoma Prevention Programme 2
CAPS	Colorectal Adenoma Prevention Study
CHIP	Clonal hematopoiesis of indeterminate potential; Children’s International Polyposis
COX	Cyclooxygenase
CRC	Colorectal cancer
DFMO	Difluoromethylornitine
DNA	Deoxyribonucleic acid
FAP	Familial adenocarcinoma polyposis
HIF-1α	Hypoxia-inducible factor 1-alpha
HNPCC	Hereditary non-polyposis colorectal cancer
IL-1β	Leukocytic pyrogen
IL-6	Interleukin 6
IL-23	Interleukin 23
ITT	Intention-to-treat analysis
IκB	Inhibitor of nuclear factor kappa B
NF-κB	Nuclear factor-kappa B
NSAIDs	Non-steroidal anti-inflammatory drugs
PGHS	Prostaglandin endoperoxide synthase
PPARs	Peroxisome proliferator-activated receptors
PreSAP	Prevention of Colorectal Sporadic Adenomatous Polyps
STAT3	Signal transducer and activator of transcription 3
RNA	Ribonucleic acid
TDP	Time to disease progression
TNF-α	Tumor necrosis factor-alpha
WHS	Women’s Health Study
15-LOX-1	15-Lipooxygenase 1