Table 1.

Proposed mechanisms leading to obesity-induced hypothalamic inflammation.

Stimuli of Inflammatory Mechanisms	Mechanisms
Saturated fatty acids	Activation of TLR-4 pathway, Increased proinflammatory cytokines, Microglia activation
Saturated fatty acids, Hyperlipidemia Hyperglycemia	ER stress response
Western diet	Increased BBB permeability
High-fat diet	Disrupted autophagy