Table 1.
Demographic characteristics of asthmatics according to the presence of IgG and IgA against Chlamydia pnaumoniae
| Chlamydia pn IgA−, IgG− |
Chlamydia pn IgA−, IgG + |
Chlamydia pn IgA + , IgG + |
|
|---|---|---|---|
| N | 145 (35.5%) | 193 (47.5%) | 68 (17%) |
| Gender (F, %) | 68 | 63 | 49*## |
| Age (years) | 47 ± 16 | 51 ± 17* | 57.5 ± 13***# |
| Age of onset (years) | 34 ± 22 | 35 ± 22 | 39 ± 22 |
| Asthma duration (years) | 8 (1–23) | 10 (3–26) | 14.5 (2.5–25)* |
| BMI (Kg/m2) | 26.5 (22.6–29.4) | 27 (23.4–30.9) | 26.4 (23.3–30) |
| Tobacco | |||
| Smokers (%, PY) | 12.4 (13 (0.3–60) | 18.1 (21 (1.4–58) | 19.1 (25 (4–68) |
| Ex-smokers (%, PY) | 27.6 (9 (0.2–75) | 25.9 (16 (0.8–83) | 35.3 (22 (0.8–75) |
| Non-smokers (%) | 60 | 56 | 46 * |
| Environment | |||
| City (%) | 24 | 23 | 27 |
| Country side (%) | 38 | 44 | 47 |
| Suburban (%) | 30 | 26 | 22 |
| Atopy (Y, %) | 50 | 50 | 49 |
| Exacerbations (n) | 0.88 ± 1.70 | 0.86 ± 1.60 | 1.06 ± 2.04 |
| Classification | |||
| Mild (%) | 56 | 55 | 38*# |
| Moderate (%) | 16 | 19 | 29* |
| Severe (%) | 28 | 26 | 31 |
| Dose of ICS (equivalent of beclomethasone) | 760 ± 825 | 795 ± 1034 | 1022 ± 1042* |
| Oral corticoids (Y, %) | 10 | 11 | 10 |
| Biologics (Y, %) | 5 | 3 | 0 |
| Anti-IgE (n) | 1 | 2 | 0 |
| Anti-IL5 (n) | 4 | 2 | 0 |
| Long-term macrolides (Y, %) | 2 | 0.5 | 3 |
| Antileukotrienes (Y, %) | 23 | 29 | 29 |
| ACT | 15.5 ± 5.2 | 15.5 ± 5.6 | 14.5 ± 0.7 |
| ACQ | 1.88 ± 1.16 | 1.99 ± 1.30 | 2.19 ± 1.13 |
| AQLQ | 4.61 ± 1.41 | 4.52 ± 1.48 | 4.29 ± 1.28 |
Results are presented as mean + SD for categorial variables and median (IQR) for skewed distribution. *: Significantly different from IgA-IgG-group
*: Different from IgA−/IgG−. #: Different from IgA− IgG +
*p < 0.05
**p < 0.001
***p < 0.0001
#p < 0.05
##p < 0.001
###p < 0.0001