Table 1.

Demographics of patients in 2004, 2009 and 2015

		2004	2009	2015	p value
age	(year)	62.2	66.3	70.1	N/A
affected time	(year)	18.1	23.1	28.5	N/A
CRP	(mg/dl)	1.31	0.97	0.79	0.275
ESR	(mm/hr)	52.1	27.9*	34.7**	0.001
MMP-3	(ng/dl)	179.5	149.1	171.5	0.743
DAS28		no data	3.17	3	0.32

Numbers show the averages at each endpoint. Analysis of variance with post hoc Bonferroni test was used for multiple comparison

CRP C-reactive protein, ESR erythrocyte sedimentation rate, MMP matrix metalloprotease, DAS disease activity score

*: p = 0.001, *: p = 0.019