Fig. 2.

Silencing of circCTNNA1 suppressed CRC cell progression. a The transfection efficiencies of si-circCTNNA1#1 and si-circCTNNA1#2 were confirmed by detecting circCTNNA1 expression using qRT-PCR in SW620 and SW480 cells. b–k SW620 and SW480 cells were transfected with si-con or si-circCTNNA1#2. The viability, number of colonies, apoptotic rate, cell cycle, migration and invasion of cells were determined using CCK8 assay (b, c), colony formation assay (d), flow cytometry (e–g), and transwell assay (h, i). j, k The protein expression of E-cadherin and N-cadherin was measured using WB analysis. **p < 0.01, ***p < 0.001