Table 2.

DUBs and target proteins involved in ER stress.

DUB	Target	Impact on ER stress	References
ERAD
USP13	Ubl4A	Promotes ERAD	[137]
USP19	TCRa and other ERAD substrates	Saves the substrate degradation caused by ERAD	[138]
	HRD1	Maintains normal ERAD process	[139]
YOD1	RI332 and other ERAD substrates	Promotes the reverse transport of misfolded proteins	[140,141]
UPR
USP14	IRE1α	Inhibits ER stress-induced cell death	[142,143]
BAP1	CHOP/ATF3	Inhibits ER stress-induced apoptosis	[144]
USP5	ORP8	Increases ER stress	[145]
USP19	?	Inhibits the UPR reaction	[146]