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Example of a synergistic (A), indifferent (B), and antagonistic (C) interaction of two antifungals according to the checkerboard method and calculated by the FIC index. If there is no FIC index > 4, then the lowest FIC index is retained. If there is at least one FIC index > 4, then the highest FIC index is retained. Synergy is defined as a FIC index ≤ 0.5, indifference as a FIC index > 0.5 to 4, and antagonism as a FIC index > 4.
