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. 2021 Feb 5;49(4):1935–1950. doi: 10.1093/nar/gkab030

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — PAX6 and PAUPAR coordinately regulate the expression of a large number of neural genes. (A) RNA-seq scatterplot shows differential expression in control and PAU-PAKI cells on day 16 of dorsal neural differentiation. (B) Analysis of significant GO terms in genes that were downregulated by at least 2-fold in the PAU-PAKI cells compared with control cells. (C) RNA-seq scatterplot shows differential expression in control and PAX6KO cells on day 16 of dorsal neural differentiation. (D) Analysis of significant GO terms in genes that were downregulated by at least 2-fold in the PAX6KO cells compared with control cells. (E) The number of downregulated genes (at least2-fold) in PAU-PAKI cells and PAX6KO cells compared with control cells on day 16 of dorsal neural differentiation. (F) Heat map of significantly regulated genes in control, PAU-PAKI and PAX6KO cells on day 16 of dorsal neural differentiation. (G) Expression of representative downregulated genes related to neural differentiation (e.g. SOX1, POU3F2, POU3F3, NR2F1 and MSX1) in control, PAU-PAKI and PAX6KO cells on day 16 of dorsal neural differentiation. (H) Analysis of significant GO terms in genes that were downregulated by at least 2-fold in both PAU-PAKI and PAX6KO cells compared with control cells. Data are presented as mean ± SEM. **P< 0.01, ***P< 0.001 (t-test). See also Supplementary Figure S3.