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. 2021 Feb 5;49(4):1935–1950. doi: 10.1093/nar/gkab030

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — PAUPAR regulates PAX6 proper binding to the target neural genes. (A) Average profiles of PAX6 enrichment in genome-wide level of control and PAU-PAKI cells on day 16 of dorsal neural differentiation. (B) PAX6 binding motif in control and PAU-PAKI cells on day 16 of dorsal neural differentiation. (C) Genome-wide heatmaps of PAX6 enrichment of target genes in control and PAU-PAKI cells on day 16 of dorsal neural differentiation. (D) Analysis of significant GO terms in PAX6 binding diminished genes. (E) Genome browser screenshots of PAX6 ChIP-seq on SOX1, POU3F3, MSX1 and NR2F1 in control and PAU-PAKI cells on day 16 of dorsal neural differentiation. (F) Enrichment of PAX6 on SOX1 (TSS +1300), POU3F3 (TSS +1000), MSX1 (TSS +1000) and NR2F1 (TSS +1500) genomic region in control and PAU-PAKI cells on day 16 of dorsal neural differentiation. (G) Enrichment of PAX6 on TBR1 (TSS +200) and TBR2 (TSS –1000) genomic region in control and PAU-PAKI cells on day 25 of dorsal neural differentiation. (H, I) Enrichment of PAX6 on SOX1 (TSS +1300), POU3F3 (TSS +1000), MSX1 (TSS +1000) and NR2F1 (TSS +1500) genomic region after PAUPAR overexpression in the PAU-PAKI cells on day 16 (H), TBR1 (TSS +200) and TBR2 (TSS -1000) genomic region on day 25 (I) of dorsal neural differentiation. Data are presented as mean ± SEM. *P< 0.05, **P< 0.01, ***P< 0.001 versus CTRL group (F–I); ^#P< 0.05, ^##P< 0.01, ^###P< 0.001 versus PAU-PAKI + ptPAU-dox group (H and I) (t-test). See also Supplementary Figure S4.