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. 2021 Feb 5;49(4):2085–2101. doi: 10.1093/nar/gkaa1292

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Model of MazF impact on cell physiology and its implication on cell survival and dormancy. MazE degradation unleashes MazF endoribonuclease activity. MazF cleaves many RNAs and suppresses transcription and translation of many genes rather than a particular set of genes. MazF changes the translational program and specifically affects several pathways: co-translational quality control, ribosome hibernation and recycling, cell division and cell wall thickness. Activation of these pathways may contribute to reversible bacteria dormancy, which allow cells to survive unfavorable growth conditions. Impact of MazF is indicated in red arrows. Activation of the other pathways by MazF is also possible.