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. 2021 Feb 1;49(4):1951–1971. doi: 10.1093/nar/gkab032

Figure 7.

Figure 7.

Model examples of GR target loci differentially regulated by GR SUMOylation. Example of genome browser tracks of PER1 (left) and IRS1 (right) loci showing GR ChIP-seq, ATAC-seq, NCOA1 and SUMO2/3 ChIP-seq data from GRwt and GR3KR cells. PER1 is Dex induced in both cells. IRS1 is Dex induced only in GR3KR cells. Dex induction of IRS1 is increased in GRwt cells upon ML-792 treatment. PER1 loci harbor two GR binding sites, one at pre-accessible and one at de novo chromatin site. GRwt and GR3KR can bind to both sites and recruit NCOA1. At de novo site, both receptor forms induce chromatin accessibility. IRS1 locus harbors two GR3KR specific binding sites all de novo chromatin sites. GR3KR induces the recruitment of NCOA1 and chromatin accessibility at these sites. GRwt is able to bind to these sites upon ML-792 treatment.