Table 4.

Top pathway–tissue combinations showing distinct agreement between human and a model organism

	Mouse	Rat	Pig	Mouse & rat	Rat & pig	Mouse & pig
Pathway–tissue pairs	24	35	41	44	20	36
# pathways	20	28	34	34	17	27
Average JI	0.72	0.74	0.72	0.69	0.62	0.70
# pathways by tissue
Heart	4	7	5	10	1	2
Kidney	3	8	4	8	1	5
Liver	2	3	6	6	2	4
Lung	7	2	8	4	4	12
Muscle	4	1	10	9	1	4
Nerv. system	3	5	2	5	6	6
Spleen	1	9	6	2	5	3

This table shows the top 200 pairs, while Supplementary Table S10 gives an overview of the top 100 and 500 pathway–tissue pairs. The first three columns indicate the numbers of pairs, for which one of the model organisms (mouse, rat or pig) is specifically more consistent with human than the other two. The last three columns refer to the pairs, which are shared between two model organisms and thus consistent with human in a similar way for both organisms. The average Jaccard index (JI) for all pathway–tissue pairs assigned to a group is also listed. For each tissue row, the number of (#) pathways assigned to this tissue is listed. Numbers shown in bold indicate the tissue covered by the highest number of pathways for each column.